June 21, 2013

Outcomes in systemic sclerosis-related lung disease after lung transplantation


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Although systemic sclerosis (SSc) causes fibrosis and small vessel vasculopathy in multiple organ systems, pulmonary disease, including interstitial lung disease and/or pulmonary hypertension, is the leading cause of death in these patients. Due to their multi-organ involvement, candidacy for lung transplantation may be controversial. In particular, esophageal dysmotility and gastroparesis may increase aspiration-induced injury to the lung allografts. Twenty-three patients with SSc-related pulmonary disease underwent lung transplantation in this single-centre retrospective study, and post-transplant outcomes were compared to patients with lung transplants for non-SSC interstitial lung disease. Survival and development of bronchiolitis obliterans syndrome were not different between the groups, and the SSc group had lower rates of acute rejection. Esophageal dysmotility was not associated with worsened outcomes in these patients.

Lung Transplantation

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