Outcomes of Simultaneous Liver and Kidney Transplantation in Relation to a High Level of Preformed Donor-Specific Antibodies
Liver transplants rarely experience antibody-mediated rejection, and it has been suggested that a liver transplant can protect the kidney if a simultaneous transplant is performed. In this single-center study, patients who received a simultaneous liver-kidney transplant had a higher risk of acute rejection, but similar renal function and patient and graft survival, whether or not there were donor-specific antibodies (DSA) present or even if the crossmatch test was positive. This is in contrast to other studies showing worse outcomes when DSA are present. Given the increasing incidence of simultaneous liver-kidney transplants, deciding on the best strategy for organ allocation will be crucial in the future.