July 9, 2012

Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients


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Organ preservation fluid is not routine cultured at most centers. However, there are several reports of candida transmission from organ preservation fluid. ¾In this single-center retrospective study, the authors describe the microbiology of organ preservation fluid samples for 331 organs. Preservation fluid was positive in more than 60% of cases although the majority of these were low risk organisms such as coagulase negative Staphylococcus. However, some important organisms were isolated including Staphylococcus aureus, Gram-negative bacilli, and Candida spp. and these appear to increase the risk of post-operative infections. It is very likely, however, that the majority of organisms isolated would be covered by perioperative antimicrobials and only unusual organisms such as multidrug resistant bacteria or fungi may be transmitted. Therefore, it still remains unclear whether preservative fluid cultures are useful to guide post-operative antimicrobial management.

Transplant Infectious Disease

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