February 23, 2012

Posttransplant Donor-Specific Anti-HLA Antibodies Negatively Impact Pancreas Transplantation Outcome


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Continuing on with other recent developments related to antibody-mediated rejection of pancreas transplants, the current study reinforces the strong effect of donor-specific antibodies (DSA) on graft survival in simultaneous pancreas-kidney transplant patients. A total of 167 pancreas transplants (152 pancreas-kidney) were followed for the  development of HLA antibodies and DSA during 9 years of follow-up. The data shows a higher number of rejection episodes in patients who had HLA antibodies compared to HLA antibody negative patients, and particularly higher number of rejections in DSA+ patients. Following a similar pattern to those observed in other organs, pancreas and kidney graft survival were significantly lower in DSA+ patients. Thus pancreas allografts, like other vascularized allografts, show poor outcomes in the presence of post-transplant DSA.

Pancreas Transplantation

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