April 1, 2013

Pre-transplant malignancy: an analysis of outcomes after thoracic organ transplantation


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Using the UNOS database, this retrospective study compared survival post lung-transplantation or orthotopic heart transplantation in patients with pre-transplant malignancy (PTM) to a matched cohort without PTM. The incidence of PTM in lung transplants was 5.4% and in orthotopic heart transplants was 5.6%. No significant difference was noted in survival at 30-days, 1-year, and 5-years when compared to patients without PTM. No specific tumor types were associated with increased mortality in lung transplant patients, but in orthopic heart transplants, leukemia, lymphoma, or meloma were associated with increased mortality at all 3 time points.

Cardiac Transplantation, Lung Transplantation

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