February 23, 2012

Prevention and treatment of alloantibody-mediated kidney rejection


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The problem of antibody-mediated rejection (ABMR) due to donor specific HLA antibodies continues to challenge transplant programs as we struggle to find effective treatments. This very detailed review carefully outlines the various treatment options attempted in dealing with ABMR or desensitization including some not so common protocols such as immunoadsorption. Furthermore, insightful views regarding organ allocation are also discussed that could minimize the risk of post-transplant ABMR such as incorporation of more detailed assessment of HLA incompatibilities based on characterization of immunogenic epitopes mismatched between donor and recipient. Discussion of novel anti-humoral treatments is also included.

Renal Transplantation

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