May 23, 2012

Prope tolerance to heart allografts in mice associated with persistence of donor interleukin-10-transduced stem cells


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Rejection, which requires life long immunosuppressive agents and the associated morbidity/side-effects, remains the main limiting factor in longevity following heart transplantation. �Prope� or almost tolerance is a state of recipient graft acceptance allowing for low, non-toxic immunosuppression dosages that may be eventually discontinued. This study explored the effects of donor interleukin-10-transduced stem cells in two different mice models of organ transplantation; including a heart transplantation model. Although �pope� tolerance in heart transplantation remains a distant clinical reality, this study highlights the possibilities that may lie ahead.

Cardiac Transplantation

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