November 18, 2011

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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The approach to desensitization varies between cardiac transplant centers.  This pilot study by Kobashigawa et al, explores a new approach in desensitization attempts in patients refractory to an IVIg/rituximab combination therapy.  Bortezomib successfully reduced cPRA in the majority of patients with an acknowledged increase risk of infection.

Cardiac Transplantation

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