October 30, 2012

Renal grafts from anti-hepatitis B core-positive donors: a quantitative review of the literature.


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The use of organs from Hepatitis B core antibody positive donors is an area of controversy. Not all centers are comfortable using these donors due to the risk of hepatitis B transmission. Mahboobi et al., reviewed nine studies that looked at the risk of HBV transmission from these donors. Of 1385 kidney transplant recipients, 45 showed seroconversion of Hepatitis B markers and the total rate of seroconversion was 3.24%. None experienced a symptomatic hepatitis or a decrease in graft survival. The authors highlight that these grafts could be safely used thereby expanding the donor pool. It is important to determine whether monitoring for seroconversion or prophylaxis is required after transplantation of such organs. More importantly, the risk could be further reduced by ensuring that all transplant candidates are up to date with Hepatitis B vaccination.

Transplant Infectious Disease

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