April 14, 2012

Revisiting the pathologic finding of diffuse alveolar damage after lung transplantation


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Diffuse alveolar damage (DAD) is a common, non-specific histologic finding in lung transplant recipient biopsies. This study reviewed the transbronchial biopsy results and clinical records of 824 patients who had lung transplantations between 1996 and 2010. Early DAD, identified within 3 months, was detected in 37%, and late new-onset DAD, after 3 months, was detected in 13% of patients. Mortality was significantly higher in the patients with early DAD. Early DAD was also associated with earlier onset of bronchiolitis obliterans syndrome, but late new-onset DAD was associated with development of the restrictive allograft syndrome. Although non-specific, the time of development of DAD in lung transplants may be predictive of important clinical outcomes in lung transplant recipients.

Lung Transplantation

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