November 18, 2011

Safety and efficacy of early aggressive versus cholesterol-driven lipid-lowering strategies in heart transplantation: A pilot, randomized, intravascular ultrasound study


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The safety and efficacy of pravastatin, simvastatin and atorvastatin in heart transplant recipients have been tested in several single-center studies. This study demonstrated that a titrated-dosing approach of fluvastatin is as effective as a maximal early dose in achieving target LDL levels at 1year post transplant. The maximal-dosing approach seems to provide additional benefit by allowing a more rapid lipid-lowering effect and a possible delay in the development of coronary intimal hyperplasia an early indicator of graft vasculopathy.  Of note, maximal intimal thickness (MIT) ≥ .5mm did not occur in a large number of patients in either arm resulting in an underpowering of this IVUS portion of the study.

Cardiac Transplantation

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