February 12, 2010

Screening for De Novo Anti-Human Leukocyte Antigen Antibodies in Nonsensitized Kidney Transplant Recipients Does Not Predict Acute Rejection


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Several studies have shown the development of anti-donor HLA-antibodies after transplantation is a risk factor for graft loss, suggesting that antibodies should be monitored to identify patients at risk of immunologic events. In this study, patients were prospectively studied for the development of antibodies during the first year post-transplant. Anti-HLA antibodies developed at the same time or after episodes of acute rejection, and was therefore not predictive of acute rejection.

Renal Transplantation