July 4, 2011

Solid Organ Allograft Survival Improvement in the United States: The Long-Term Does Not Mirror the Dramatic Short-Term Success


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This article reviews registry outcomes of heart, liver, lung, pancreas and intestine transplantation in the United States over a twenty-year period. While one-year graft survival and first-year attrition rates have made considerable progress over this time, attrition rates over the long-term have shown little improvement. This highlights the need to focus efforts on the causes of late graft loss, which often include chronic fibrosis, immunologic damage and recurrent disease, as opposed to acute rejection.

 

Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation

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