July 4, 2011

Summary of FDA Antibody-Mediated Rejection Workshop


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Although several agents are currently used for the treatment of antibody-mediated rejection (AbMR), the true efficacy of these therapies remains is unknown due to limited/ anecdotal experience. The following article reviews the results of the FDA-sponsored workshop on AbMR held in June of 2010. This workshop outlined the challenges facing the transplant community with the problem of AbMR including: selection of appropriate controls, small patient populations, problems relating to the reliability of HLA antibody testing methods and histologic markers used for the diagnosis of AbMR, and problems with animal models. The workshop highlighted considerations for the design of clinical trials for potential AbMR therapies.

 

Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation, Transplant Infectious Disease

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