Posts Tagged ‘acute rejection’

October 1, 2011

Very late heart transplant rejection is associated with microvascular injury, complement deposition and progression to cardiac allograft vasculopathy


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There is ongoing debate as to the clinical importance of late rejection following heart transplantation detected on routine biopsy.  More and more programs have moved away from routine biopsies beyond 3-5 years post-transplant, negating the possibility of even detecting this late rejection.  In this provocative study, the authors assess both the pathologic charactistics, presence of […]

No Comments Posted in Cardiac Transplantation
October 1, 2011

Doppler tissue imaging in children following cardiac transplantation: A comparison to catheter-derived hemodynamics


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In this study, the authors continue the quest to identify echocardiography-derived indices sensitive enough to diagnose or predict rejection, or further down the road, maybe even early coronary allograft vasculopathy.  Though the primary aim was not proven (the ratio of early mitral inflow velocity compared to annular tissue velocity, septal E:Ea; did not correlate with […]

No Comments Posted in Cardiac Transplantation
August 14, 2011

The ORION Study: Comparison of Two Sirolimus-Based Regimens versus Tacrolimus and Mycophenolate Mofetil in Renal Allograft Recipients


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This randomized controlled trial in de novo renal transplant recipients compared a standard immunosuppressive protocol of daclizumab induction, tacrolimus, mycophenolate mofetil (MMF) and steroids, to either: sirolimus and tacrolimus, with tacrolimus discontinued by four months post-transplant, or sirolimus and MMF. The sirolimus and MMF group was stopped early due to a high incidence of acute […]

No Comments Posted in Renal Transplantation
August 14, 2011

Improved Rejection Prophylaxis With an Initially Intensified Dosing Regimen of Enteric-Coated Mycophenolate Sodium in De Novo Renal Transplant Recipients


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Previous studies have defined a therapeutic area under the curve for mycophenolic acid (MPA) in the early post-transplant period, although the majority of centers do not perform routine MPA monitoring. This paper presents results of a randomized controlled trial comparing an initial higher dose of MPA to standard dosing in patients treated with steroids, cyclosporine […]

No Comments Posted in Renal Transplantation
June 18, 2011

HLA Mismatches Influence Lung Transplant Recipient Survival, Bronchiolitis Obliterans and Rejection: Implications for Donor Lung Allocation


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HLA matching is not considered in recipient selection for lung transplantation.  This study retrospectively examined a large cohort of lung transplants from the Organ Procurement and Transplantation Network (OPTN) database to evaluate the effect of HLA matching on survival, bronchiolitis obliterans, and acute rejection. Significantly improved survival was seen in recipients with fewer total HLA […]

No Comments Posted in Lung Transplantation