Posts Tagged ‘Antibody-mediated rejection’

October 25, 2013

Microarray Diagnosis of Antibody-Mediated Rejection in Kidney Transplant Biopsies: An International Prospective Study (INTERCOM)


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Although considered the gold standard, histologic examination of renal transplant biopsies, expert pathologists frequently disagree on their interpretation of the same sample. The authors of this paper have developed criteria for antibody-mediated rejection based on mRNA expression in biopsy samples detected by microarrays. In this study, they validate their previous findings in a cohort of […]

No Comments Posted in Renal Transplantation
October 7, 2013

Acute antibody-mediated rejection after lung transplantation


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There is no consensus on the characteristic features of antibody-mediated rejection (AMR) in lung transplantation. This retrospective cohort study characterized the clinical and pathological features of acute AMR after lung transplantation. Twenty-one patients were identified based on the presence of circulating donor-specific antibodies, histologic evidence of acute lung injury, C4d deposition, and clinical allograft dysfunction.

No Comments Posted in Lung Transplantation
September 26, 2013

Acute Cellular and Antibody-Mediated Rejection of the Pancreas Allograft: Incidence, Risk Factors and Outcomes

Antibody-mediated pancreas transplant rejection is a relatively recently recognized entity. In this retrospective study, the rate of antibody-mediated rejection post-pancreas transplant was similar to that of acute cellular rejection. Class I DSA were more predictive of antibody-mediated rejection than class II DSA. Antibody-mediated rejection should be considered in all patients with pancreas graft dysfunction post-transplant.

No Comments Posted in Pancreas Transplantation, Renal Transplantation
September 26, 2013

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival


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The ability to detect anti-HLA antibodies is very sensitive and specific, but it is not clear if all antibodies are the same. Specifically, some antibodies may bind and activate complement better than others. In this retrospective study, the presence of antibodies that could fix C1q and initiate the complement cascade was associated with higher rates […]

No Comments Posted in Renal Transplantation, Uncategorized
August 2, 2013

Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts


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The gold standard fro diagnosing acute rejection remains biopsy. A non-invasive test that could reliably diagnose rejection would be an important step forward. In this study, a set of three different RNA molecules in the urine of renal transplant recipients showed a high degree of sensitivity for acute cellular rejection, and distinguished it from antibody-mediated […]

No Comments Posted in Renal Transplantation
June 21, 2013

Molecular Diagnosis of Antibody-Mediated Rejection in Human Kidney Transplants


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The diagnosis of late antibody-mediated rejection (AbMR) by conventional methods can be inaccurate due to the high degree of variability in the histologic lesions and the guidelines used to interpret such lesions. In the study by Sellares et. al. a gene expression based classifier was developed to assign the probability of AbMR to each biopsy […]

No Comments Posted in Renal Transplantation
June 21, 2013

Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: A single-center, retrospective study.


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Approximately 10 – 20% of heart transplant recipients will develop AMR. Standardized nomenclature has improved the diagnosis. This single center study revisits the risks of Class I and II DSA to C4D +IF and graft failure. C4d staining correlated better with graft failure in patients with DSA to only Class I or DSA to both […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Pathologic findings in lung allografts with anti-HLA antibodies


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Antibody-mediated rejection is a well recognized cause of accelerated allograft dysfunction in heart and kidney transplantation in the setting of de novo donor specific antibodies (DSA). Development of de novo DSA in lung transplant recipients has been linked with early development of bronchiolitis obliterans syndrome (BOS), although the role of antibody-mediated rejection in BOS is […]

No Comments Posted in Lung Transplantation
April 1, 2013

Donor-Specific Antibodies to Class II Antigens Are Associated With Accelerated Cardiac Allograft Vasculopathy: A Three-Dimensional Volumetric Intravascular Ultrasound Study.


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This preliminary study from Mayo clinic demonstrated that cardiac transplant patients with preformed class II DSA may be at increased risk for accelerated graft vasculopathy on consecutive 3D IVUS. Although this technology may not be available at all centers, this sstudy provides further weight to the potential clinical impact of class II DSA.

No Comments Posted in Cardiac Transplantation
November 26, 2012

Intentional ABO-incompatible heart transplantation: A case report of 2 adult patients.


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Although ABO incompatible transplantation is accepted within the pediatric population, there have been few attempts in adults. This group from Sweden, accepted patients with anti-A or anti-B antibody titer≤1:8 for ABO-incompatible heart transplantation without any special pre-treatment and patients with antibody titers of IgG 1:16 and 1:32, provided 1 apheresis session could be performed immediately […]

No Comments Posted in Cardiac Transplantation