Posts Tagged ‘Antibody-mediated rejection’

May 23, 2012

A Novel Pathway of Chronic Allograft Rejection Mediated by NK Cells and Alloantibody


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A major obstacle to the long-term survival of human heart allografts is chronic allograft vasculopathy (CAV), a pathologic state thought to be mediated by donor specific HLA antibody (DSA). This article defines the mechanism for DSA-mediated CAV in a mouse model. The analysis points to a clear role for NK cells in the generation of […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation.


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Antibody mediated rejection (AMR) is a well described phenomenon in kidney and heart transplant but its presence and impact on intestinal transplantation is unclear. AMR might contribute to the severity and relatively high rate of steroid resistant acute rejection in intestinal transplantation. This prospective study measured and correlated donor specific antibodies (DSA) levels to episodes […]

No Comments Posted in Liver Transplantation
February 23, 2012

Prevention and treatment of alloantibody-mediated kidney rejection


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The problem of antibody-mediated rejection (ABMR) due to donor specific HLA antibodies continues to challenge transplant programs as we struggle to find effective treatments. This very detailed review carefully outlines the various treatment options attempted in dealing with ABMR or desensitization including some not so common protocols such as immunoadsorption. Furthermore, insightful views regarding organ […]

No Comments Posted in Renal Transplantation
February 23, 2012

Allosensitization and outcomes in pediatric heart transplantation


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Allosensitization of pediatric heart transplant candidates continues to be a problem with uncertainty on the best clinical approach to manage these patients. Using data from the Pediatric Heart Transplant Study, the current study examined >3000 patients listed for heart transplantation of which 2237 were transplanted with available panel reactive antibody (PRA) data. The outcomes for […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients


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Antibody-mediated rejection (ABMR)in the presence of high levels of donor-specific antibodies (DSA) likely involves complement activation as part of the mechanism of graft damage. This study examined the efficacy of inhibiting complement activation by neutralizing C5 with a humanized anti-C5 antibody; eculizumab. The effect of anti-C5 treatment was assessed in 26 highly sensitized recipients of […]

No Comments Posted in Renal Transplantation
February 23, 2012

A longitudinal study of the course of asymptomatic antibody-mediated rejection in heart transplantation


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Recent studies directly linked asymptomatic AMR with a higher risk of cardiac allograft vasculopathy and mortality.  The study provides insight on the incidence of asymptomatic AMR early and late after transplantation. The course of untreated asymptomatic AMR appears to be influenced by the severity of its initial presentation and, to a lesser extent, the time […]

No Comments Posted in Cardiac Transplantation
December 19, 2011

Impact of virtual cross match on waiting times for heart transplantation


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The concept of virtual crossmatching has been adopted by the cardiac transplant community and has expanded the donor pool by its feasibility.  In contrast, prospective cross matches which required donor cells and approximately 4 hours to perform limited the donor pool to regional centers where recipient blood could be sent.  Within Canada, the use of […]

No Comments Posted in Cardiac Transplantation
November 18, 2011

Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts-updated Banff grading schema


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The Banff consensus, originally developed as a histopathological guideline to diagnoses in transplanted kidneys, has been adopted by other transplanted organs. Pancreas transplant specialists developed and implemented their first set of guidelines in 2008 with much of the detail pertaining to T-cell-mediated rejection. This latest set of guidelines now addresses the criteria proposed for the […]

No Comments Posted in Uncategorized
November 18, 2011

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients


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There has been much interest in transplantation around eculizumab, a monoclonal antibody that blocks formation of the membrane attack complex of the complement cascade. In this single-centre, non-randomized study, patients with donor-specific antibody who were treated with eculizumab had a significantly lower rate of antibody-mediated rejection that a group of historical controls. There was also […]

No Comments Posted in Renal Transplantation
August 14, 2011

Modifiers of complement activation for prevention of antibody-mediated injury to allografts


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Antibody mediated rejection (ABMR) involves complement activation through the classical pathway due to donor specific antibody binding to allograft endothelium. The major strength of this review is its extensive overview of complement biology and its role in the damage it incurs to the allograft during episodes of ABMR. It also covers current approaches used to […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation