Posts Tagged ‘bortezomib’

May 23, 2012

Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy


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Experience with proteasome inhibitors (PI) for treating antibody-mediated rejection (ABMR) and HLA antibody removal is increasing. However, the durability of the effects PI on HLA antibody removal is unknown. This study examines this question from a unique point of view due to the use of the PI bortezomib as either a combination therapy or a […]

No Comments Posted in Renal Transplantation
April 14, 2012

Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy


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Experience with proteasome inhibitors (PI) for treating antibody-mediated rejection (ABMR) and HLA antibody removal is increasing. However, the durability of the effects PI on HLA antibody removal is unknown. This study examines this question from a unique point of view due to the use of the PI bortezomib as either a combination therapy or a […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
November 18, 2011

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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The approach to desensitization varies between cardiac transplant centers.  This pilot study by Kobashigawa et al, explores a new approach in desensitization attempts in patients refractory to an IVIg/rituximab combination therapy.  Bortezomib successfully reduced cPRA in the majority of patients with an acknowledged increase risk of infection.

No Comments Posted in Cardiac Transplantation
July 4, 2011

Early and Late Acute Antibody-Mediated Rejection Differ Immunologically and in Response to Proteasome Inhibition


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Antibody-mediated rejection (AbMR) requires the production of donor specific antibody (DSA) by recipient plasma cells and can present at early or late times post-transplant. Bortezomib is a proteasome inhibitor (PI) approved by the FDA for treatment of multiple myeloma that is increasingly being used off-label for the treatment of AbMR. This study, from one of […]

No Comments Posted in Renal Transplantation