Posts Tagged ‘Bridge to Transplant’

September 10, 2013

Should Eligibility for Heart Transplantation Be a Requirement for Left Ventricular Assist Device Use? Recommendations Based on a Systematic Review


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This Canadian group has generated the first systematic review of the clinical and economic effects of continuous-flow LVADs in Bridge to Transplant (BTT) and Destination Therapy (DT) patients. They conclude that evidence is sufficient to support LVAD use, regardless of transplantation eligibility status, as long as patients are carefully selected and program infrastructure and budget […]

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July 11, 2013

HeartWare ventricular assist system for bridge to transplant: Combined results of the bridge to transplant and continued access protocol trial.


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The pivotal ADVANCE Clinical Trial was a multicenter clinical trial to evaluate the HeartWare HVAD System for BTT in patients with advanced heart failure in the United States. This publication reports the analysis of combined data from the 140 BTT patients plus 192 patients from the continued access protocol (CAP) who were monitored to outcome […]

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November 18, 2011

Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: Update in a modern cohort


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This study reviewed outcomes of 1544 UNOS based patients bridged to transplant with the HeartMate II or Thoratec XVE devices based on distribution of percentage panel reactive antibody levels.  Contrary to some previously published single center studies and smaller cohorts, highly sensitized patients bridged to transplant experienced excellent survival outcomes after orthotopic heart transplantation.

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July 4, 2011

Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)


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Outcomes for patients supported on mechanical circulatory support continue to improve.The results of this post-approval study support the original findings from the pivotal clinical trial regarding the efficacyand risk profile of the HM II LVAD in a post-marketapproval “real world” BTT (Bridge to Transplant) population.Trends in patient selection and outcome are described.  Favorable improvements in […]

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