Posts Tagged ‘bronchiolitis obliterans’

June 21, 2013

Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center experience


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This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with severe cGVHD develop BO, which portends a poor prognosis. Lung transplantation may be performed for severe refractory BO. In this group, 6 […]

No Comments Posted in Lung Transplantation
April 1, 2013

Decline in 25% to 75% forced expiratory flow as an early predictor of chronic airway rejection in pediatric lung transplant recipients


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Early identification of bronchiolitis obliterans by non-invasive measures is desirable, which lead to the definition of bronchiolitis obliterans syndrome by decline in FEV1. This study hypothesized that a decline in FEF25-75 should occur before a decline in FEV1, allowing earlier diagnosis of bronchiolitis obliterans. Retrospective review of 31 pediatric lung transplantation recipients at a single […]

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November 18, 2011

Timing of Basiliximab Induction and Development of Acute Rejection in Lung Transplant Patients


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Basiliximab is a monoclonal interleukin-2 receptor antagonist commonly used for induction immunosuppression in lung transplantation.  This single centre retrospective review of 119 patients transplanted between 1994 and 2009 examined the impact of the timing of basiliximab dosing on the frequency and severity of acute rejection, the development of BOS, and overall survival.  Pre-implantation administration of […]

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October 1, 2011

Survival determinants in lung transplant patients with chronic allograft dysfunction


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Bronchiolitis obliterans syndrome is the major cause of late mortality after lung transplantation.  Different subtypes of chronic lung allograft dysfunction (CLAD) have been identified in recent years, and these subtypes may respond differently to treatments and have different prognoses.  This retrospective single-centre study identified CLAD in 71 lung transplant recipients out of 294 transplantations performed, […]

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October 1, 2011

Medium-term outcome after lung transplantation is comparable between brain-dead and cardiac-dead donors


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Donation after cardiac death (DCD) is being utilized to extend the donor organ shortage in lung transplantation.  This retrospective study compared the actuarial survival rates at 6 months, 1 year, and 3 years between a cohort of 21 DCD lung transplant recipients and donation after brain death lung transplant recipients, finding no significant differences.  Freedom […]

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