Posts Tagged ‘bronchiolitis obliterans syndrome’

July 7, 2013

Anti-reflux surgery for lung transplant recipients in the presence of impedance-detected duodenogastroesophageal reflux and bronchiolitis obliterans syndrome: A study of efficacy and safety


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Bronchiolitis obliterans syndrome (BOS) has been linked to aspiration of gastric refluxate, thought to trigger an inflammatory process. This retrospective study aimed to determine the safety of anti-reflux surgery in lung transplant recipients and also to assess its effect on lung function. Forty lung transplant recipients with histologic evidence of gastroesophatgeal reflux aspiration on lung […]

No Comments Posted in Lung Transplantation
June 21, 2013

Outcomes in systemic sclerosis-related lung disease after lung transplantation


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Although systemic sclerosis (SSc) causes fibrosis and small vessel vasculopathy in multiple organ systems, pulmonary disease, including interstitial lung disease and/or pulmonary hypertension, is the leading cause of death in these patients. Due to their multi-organ involvement, candidacy for lung transplantation may be controversial. In particular, esophageal dysmotility and gastroparesis may increase aspiration-induced injury to […]

No Comments Posted in Lung Transplantation
June 21, 2013

Pathologic findings in lung allografts with anti-HLA antibodies


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Antibody-mediated rejection is a well recognized cause of accelerated allograft dysfunction in heart and kidney transplantation in the setting of de novo donor specific antibodies (DSA). Development of de novo DSA in lung transplant recipients has been linked with early development of bronchiolitis obliterans syndrome (BOS), although the role of antibody-mediated rejection in BOS is […]

No Comments Posted in Lung Transplantation
April 1, 2013

Significance of and risk factors for the development of central airway stenosis after lung transplantation


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The incidence and outcomes related to post-lung transplant central airway stenosis (CAS) vary in the literature. This study aimed to identify the incidence of CAS in a large cohort of lung transplant recipients at a single centre and study the association with development of bronchiolitis obliterans syndrome (BOS) and survival. Of 467 transplanted patients, 13% […]

No Comments Posted in Lung Transplantation
October 30, 2012

A prospective interventional study on the use of extracorporeal photopheresis in patients with bronchiolitis obliterans syndrome after lung transplantation


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Extracorporeal photopheresis (ECP) is established therapy for palliation of cutaneous T-cell lymphoma, and also effective in other T-cell mediated diseases such as acute and chronic graft-versus-host disease. Indications for use of ECP in acute and chronic rejection in lung transplantation have not been established. This prospective observational study compared rate of change in lung function […]

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August 17, 2012

Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation


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Immunosuppression regimens after lung transplantation are typically based on calcineurin inhibitors. Tacrolimus is widely used as an alternative to cyclosporine, and it has been proposed that tacrolimus may reduce the development of bronchiolitis obliterans (BOS) when compared to cyclosporine. This randomized, open-label, multicenter trial compared cyclosporine to tacrolimus (both plus prednisolone and mycophenolate mofetil) for […]

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April 14, 2012

Spirometric obstructive lung function pattern early after lung transplantation


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Airflow obstruction on spirometry after lung transplantation is a common finding, with several potential causes. This study of 122 double lung transplant recipients examined the outcomes of this pattern on early post-transplant outcomes. Fourteen percent of recipients demonstrated an obstructive spirometry pattern, and these recipients had significantly lower FEV1, increased total lung capacity, and lower […]

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April 14, 2012

Revisiting the pathologic finding of diffuse alveolar damage after lung transplantation


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Diffuse alveolar damage (DAD) is a common, non-specific histologic finding in lung transplant recipient biopsies. This study reviewed the transbronchial biopsy results and clinical records of 824 patients who had lung transplantations between 1996 and 2010. Early DAD, identified within 3 months, was detected in 37%, and late new-onset DAD, after 3 months, was detected […]

No Comments Posted in Lung Transplantation
June 18, 2011

HLA Mismatches Influence Lung Transplant Recipient Survival, Bronchiolitis Obliterans and Rejection: Implications for Donor Lung Allocation


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HLA matching is not considered in recipient selection for lung transplantation.  This study retrospectively examined a large cohort of lung transplants from the Organ Procurement and Transplantation Network (OPTN) database to evaluate the effect of HLA matching on survival, bronchiolitis obliterans, and acute rejection. Significantly improved survival was seen in recipients with fewer total HLA […]

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June 18, 2011

Alloimmunity-Induced Autoimmunity as a Potential Mechanism in the Pathogenesis of Chronic Rejection of Human Lung Allografts


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Bronchiolitis obliterans syndrome remains the leading cause of morbidity and mortality after lung transplantation.  This retrospective study shows the development of donor specific antibodies during the period following lung transplantation is correlated to BOS as well as the development of antibodies to self-antigens.  Using a sensitive solid-phase assay to detect DSA, the authors demonstrated 42.7% […]

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