Posts Tagged ‘calcineurin inhibitors’

October 30, 2012

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus-Results of a Multicenter Trial


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This randomized controlled study reviews the changes in plaque morphology in maintenance heart transplant recipients on everolimus and reduced calcineurin inhibitor vs standard therapy. Conversion to everolimus and reduced calcineurin inhibitor was associated with a significant increase in calcified and necrotic intimal components and is more prominent in patients with a longer time since HTx. […]

No Comments Posted in Cardiac Transplantation
August 17, 2012

Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation


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Immunosuppression regimens after lung transplantation are typically based on calcineurin inhibitors. Tacrolimus is widely used as an alternative to cyclosporine, and it has been proposed that tacrolimus may reduce the development of bronchiolitis obliterans (BOS) when compared to cyclosporine. This randomized, open-label, multicenter trial compared cyclosporine to tacrolimus (both plus prednisolone and mycophenolate mofetil) for […]

No Comments Posted in Lung Transplantation
July 9, 2012

Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year


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Tofacitinib is the first in a new class of immunosuppressive agents that inhibit janus kinase, an important transcription factor. This randomized-controlled trial compared tofacitinib to cyclosporine in renal transplant patients. Tofacitinib showed lower rates of acute rejection and chronic changes on biopsy, with better renal function compared to a cyclosporine-based regimen. On the other hand, […]

No Comments Posted in Renal Transplantation
December 19, 2011

Meta-Analysis of Calcineurin-Inhibitor-Sparing Regimens in Kidney Transplantation


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This is a meta-analysis of papers using a variety of approaches to reduce the toxicity of calcineurin inhibitors (CnI) in renal transplantation. Papers include a variety of approaches, such as CnI minimization, delayed introduction and avoidance. All strategies showed improvements in graft function. However, while CnI minimization or use of newer agents such as belatacept […]

No Comments Posted in Renal Transplantation