Posts Tagged ‘cardiac allograft vasculopathy’

June 21, 2013

Everolimus immunosuppression in de novo heart transplant recipients: What does the evidence tell us now?


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This review article analyzes the currently available data supporting the use of everolimus in de novo heart transplant patients. Rejection, renal function, malignancy, infection and wound complications including pleural and pericardial effusions are examined. The evidence suggests that the most convincing reasons for use of everolimus are to slow the progression of CAV and to […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Characterization of 25+ year survivors of cardiac transplantation


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This single center study reviews the echocardiographic, hemodynamic and clinical characteristics of long-term survivors post heart transplant. The investigators demonstrated a significant burden of cardiac allograft vasculopathy in the setting of preserved graft function. Diastolic parameters were significantly altered.

No Comments Posted in Cardiac Transplantation
June 21, 2013

Differential Effect of Everolimus on Progression of Early and Late Cardiac Allograft Vasculopathy in Current Clinical Practice.


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CAV remains the leading cause of long-term death in heart transplant recipients. This retrospective analysis of prospectively collected data (IVUS) demonstrated everolimus independently reduced the odds for early CAV (0.14 [0.01_0.77]; p 0.02) but it did not appear to influence late CAV progression. High dose statin use was favorably associated with a reduction in both […]

No Comments Posted in Cardiac Transplantation
October 30, 2012

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus-Results of a Multicenter Trial


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This randomized controlled study reviews the changes in plaque morphology in maintenance heart transplant recipients on everolimus and reduced calcineurin inhibitor vs standard therapy. Conversion to everolimus and reduced calcineurin inhibitor was associated with a significant increase in calcified and necrotic intimal components and is more prominent in patients with a longer time since HTx. […]

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February 23, 2012

A longitudinal study of the course of asymptomatic antibody-mediated rejection in heart transplantation


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Recent studies directly linked asymptomatic AMR with a higher risk of cardiac allograft vasculopathy and mortality.  The study provides insight on the incidence of asymptomatic AMR early and late after transplantation. The course of untreated asymptomatic AMR appears to be influenced by the severity of its initial presentation and, to a lesser extent, the time […]

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December 19, 2011

Influence of Metabolic Syndrome on Development of Cardiac Allograft Vasculopathy in the Transplanted Heart


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This study explores the hypothesis that patients with metabolic syndrome would develop more cardiac allograft vasculopathy (CAV) as a consequence of the endothelial dysfunction associated with this syndrome. The authors analyzed the relationship between the presence of metabolic syndrome at the time of heart transplantation and in the first 3 months with the development of […]

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