October 7, 2013
There is no consensus on the characteristic features of antibody-mediated rejection (AMR) in lung transplantation. This retrospective cohort study characterized the clinical and pathological features of acute AMR after lung transplantation. Twenty-one patients were identified based on the presence of circulating donor-specific antibodies, histologic evidence of acute lung injury, C4d deposition, and clinical allograft dysfunction.
April 14, 2012
Diffuse alveolar damage (DAD) is a common, non-specific histologic finding in lung transplant recipient biopsies. This study reviewed the transbronchial biopsy results and clinical records of 824 patients who had lung transplantations between 1996 and 2010. Early DAD, identified within 3 months, was detected in 37%, and late new-onset DAD, after 3 months, was detected […]
October 1, 2011
Bronchiolitis obliterans syndrome is the major cause of late mortality after lung transplantation. Different subtypes of chronic lung allograft dysfunction (CLAD) have been identified in recent years, and these subtypes may respond differently to treatments and have different prognoses. This retrospective single-centre study identified CLAD in 71 lung transplant recipients out of 294 transplantations performed, […]