Posts Tagged ‘complement’

October 11, 2013

Complement-binding anti-HLA antibodies and kidney-allograft survival


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The study by Loupy et. al. shows an important role for complement-fixing (C1Q+) donor-specific HLA antibodies (DSA) in risk prediction of kidney allograft loss. The study examined 1016 kidney transplant recipients transplanted across negative T- and B-cell cytotoxic crossmatches with subsequent testing by Luminex single antigen beads for the detection of complement-fixing as well as […]

No Comments Posted in Renal Transplantation
September 26, 2013

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival


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The ability to detect anti-HLA antibodies is very sensitive and specific, but it is not clear if all antibodies are the same. Specifically, some antibodies may bind and activate complement better than others. In this retrospective study, the presence of antibodies that could fix C1q and initiate the complement cascade was associated with higher rates […]

No Comments Posted in Renal Transplantation, Uncategorized
June 21, 2013

Hypocomplementemia in Kidney Transplant Recipients: Impact on the Risk of Infectious Complications


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Post-transplant, there is no ideal measure of predicting how immunosuppressed an individual recipient is. Fernandez-Ruiz et al. assessed complement (C3 and C4) levels at 0,1,6 months post-kidney transplant in 270 patients. Those with C3 hypocomplementemia at month 1 had greater incidences of overall infection, bacterial infection and fungal infection up to month 6 post-transplant. This […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
January 28, 2013

Eculizumab for Atypical Hemolytic Uremic Syndrome Recurrence in Renal Transplantation


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Eculizumab is a monoclonal antibody that prevents complement activation. It has been found to be an effective treatment for atypical hemolytic-uremic syndrome (aHUS). This retrospective study is the largest collection of previously published and unpublished cases to date. Eculizumab was effective at both preventing and treating recurrence of aHUS.

No Comments Posted in Renal Transplantation
January 28, 2013

Eculizumab for Atypical Hemolytic Uremic Syndrome Recurrence in Renal Transplantation


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Eculizumab is a monoclonal antibody that prevents complement activation. It has been found to be an effective treatment for atypical hemolytic-uremic syndrome (aHUS). This retrospective study is the largest collection of previously published and unpublished cases to date. Eculizumab was effective at both preventing and treating recurrence of aHUS.

No Comments Posted in Renal Transplantation
February 23, 2012

Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients


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Antibody-mediated rejection (ABMR)in the presence of high levels of donor-specific antibodies (DSA) likely involves complement activation as part of the mechanism of graft damage. This study examined the efficacy of inhibiting complement activation by neutralizing C5 with a humanized anti-C5 antibody; eculizumab. The effect of anti-C5 treatment was assessed in 26 highly sensitized recipients of […]

No Comments Posted in Renal Transplantation
February 23, 2012

Recurrent Dense Deposit Disease After Renal Transplantation: An Emerging Role for Complementary Therapies


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Membranoproliferative glomerulonephritis type II, or dense deposit disease, is a rare type of renal disease caused by excessive complement deposition in the kidney. It is also associated with a high rate of recurrence post-transplant. In this case report, a patient developed recurrent dense deposit disease shortly after transplant. Despite aggressive treatment, renal function worsened and […]

No Comments Posted in Renal Transplantation
November 18, 2011

Novel C1q assay reveals a clinically relevant subset of HLA antibodies independent of immunoglobulin G strength on single antigen beads


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The first pre-transplant cross-matches were performed using complement-dependent cytotoxicity (CDC) and showed immediate clinical benefits. Current HLA antibody test methods rely on Luminex single antigen bead (SAB) technology allowing for the sensitive identification of multiple DSAs even in highly sensitized patients. However, the clinical relevance of the HLA antibodies identified by the Luminex platform remains […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
November 18, 2011

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients


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There has been much interest in transplantation around eculizumab, a monoclonal antibody that blocks formation of the membrane attack complex of the complement cascade. In this single-centre, non-randomized study, patients with donor-specific antibody who were treated with eculizumab had a significantly lower rate of antibody-mediated rejection that a group of historical controls. There was also […]

No Comments Posted in Renal Transplantation
August 14, 2011

Modifiers of complement activation for prevention of antibody-mediated injury to allografts


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Antibody mediated rejection (ABMR) involves complement activation through the classical pathway due to donor specific antibody binding to allograft endothelium. The major strength of this review is its extensive overview of complement biology and its role in the damage it incurs to the allograft during episodes of ABMR. It also covers current approaches used to […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation