Posts Tagged ‘conversion’

January 28, 2013

Conversion From Twice-Daily Tacrolimus to Once-Daily Extended Release Tacrolimus (LCPT): The Phase III Randomized MELT Trial


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Advagraf, a once-daily extended-release tacrolimus formulation was released several years ago. Another once daily formulation of tacrolimus called LCPT, has now been developed. In this non-inferiority RCT, the LCPT formulation showed similar outcomes to standard twice-daily tacrolimus with a lower daily dose. The availability of multiple once-daily tacrolimus formulations, as well as several generic versions […]

No Comments Posted in Renal Transplantation
January 28, 2013

Conversion From Twice-Daily Tacrolimus to Once-Daily Extended Release Tacrolimus (LCPT): The Phase III Randomized MELT Trial


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Advagraf, a once-daily extended-release tacrolimus formulation was released several years ago. Another once daily formulation of tacrolimus called LCPT, has now been developed. In this non-inferiority RCT, the LCPT formulation showed similar outcomes to standard twice-daily tacrolimus with a lower daily dose. The availability of multiple once-daily tacrolimus formulations, as well as several generic versions […]

No Comments Posted in Renal Transplantation
October 30, 2012

Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials


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Chronic kidney disease is a significant complication after liver transplantation. A common strategy is to add mycophenolic acid (MPA) in order to reduce or eliminate calcineurin inhibitors (CnI). Although this is a common practice, the authors were only able to find 8 randomized controlled trials assessing its effects. Use of MPA does improve renal function, […]

No Comments Posted in Liver Transplantation, Renal Transplantation
August 17, 2012

A Randomized, Controlled Study to Assess the Conversion From Calcineurin-Inhibitors to Everolimus After Liver Transplantation-PROTECT


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Post transplant inmunosuppression with calcineurin inhibitors (CNIs) is associated with renal dysfunction with an estimated rate of advanced CKD of 20% at 5 years. Everolimus is an mTOR inhibitors without the nephrotoxicity of CNIs. In this multicenter, prospective study, the authors evaluate the feasibility and effects of everolimus started at 30 days post liver transplant. […]

No Comments Posted in Liver Transplantation