Posts Tagged ‘CPRA’

February 23, 2012

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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HLA antibodies produced by plasma cells are a major barrier for patients awaiting heart transplantation due to increased wait list time, increased risk of rejection post-transplant, and decreased survival. Proteasome inhibition using bortezomib can lead to plasma cell apoptosis and potentially decrease antibody production. As already shown in renal transplants where bortezomib decreases antibody production […]

No Comments Posted in Cardiac Transplantation
November 18, 2011

How to deal with presensitized candidates for heart transplantation?


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The increased sensitivity of current HLA antibody testing methods, utilization of ventricular assist devices, and application of calculated panel-reactive antibody (cPRA) values has translated into a larger number of sensitized patients awaiting heart transplantation. The current review thoroughly outlines the changes in HLA antibody testing methods, application, and limitations. Important details relating to risk factors […]

No Comments Posted in Cardiac Transplantation
July 4, 2011

Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches


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Panel reactive antibody (PRA) has been the common measure of sensitization for transplant patients that estimates the likelihood of finding a crossmatch-compatible donor. However, estimates using class I or class II PRA values makes it difficult to estimate the actual probability of finding a suitable donor. The calculated PRA (CPRA) is a readout of unacceptable […]

No Comments Posted in Renal Transplantation