Posts Tagged ‘crossmatch’

November 28, 2013

Class II HLA Epitope Matching—A Strategy to Minimize De Novo Donor-Specific Antibody Development and Improve Outcomes


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Although testing for HLA antibodies is long-established practice in transplantation, the immune system actually makes antibodies against specific epitopes, not antigens. This study used the HLA Matchmaker program to assess whether the degree of epitope mismatching predicted the development of post-transplant class II donor-specific antibodies. Thresholds for epitope mismatching at DR and DQ were found. […]

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February 23, 2012

Prevention and treatment of alloantibody-mediated kidney rejection


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The problem of antibody-mediated rejection (ABMR) due to donor specific HLA antibodies continues to challenge transplant programs as we struggle to find effective treatments. This very detailed review carefully outlines the various treatment options attempted in dealing with ABMR or desensitization including some not so common protocols such as immunoadsorption. Furthermore, insightful views regarding organ […]

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