Posts Tagged ‘cyclosporine’

June 21, 2013

Everolimus immunosuppression in de novo heart transplant recipients: What does the evidence tell us now?


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This review article analyzes the currently available data supporting the use of everolimus in de novo heart transplant patients. Rejection, renal function, malignancy, infection and wound complications including pleural and pericardial effusions are examined. The evidence suggests that the most convincing reasons for use of everolimus are to slow the progression of CAV and to […]

No Comments Posted in Cardiac Transplantation
April 14, 2012

Conversion from Cyclosporine to Everolimus at 4.5 Months Posttransplant: 3-Year Results from the Randomized ZEUS Study

This paper prevents further results from a randomized controlled trial of mandatory conversion from cyclosporine to everolimus. There remains a higher acute rejection rate in the everolimus-treated patients. However, renal function remained better in the everolimus arm. As in many such trials, a significant number of patients treated with everolimus had to change to other […]

No Comments Posted in Renal Transplantation
April 14, 2012

Cyclosporine lowering with everolimus versus mycophenolate mofetil in heart transplant recipients: Long-term follow-up of the SHIRAKISS randomized, prospective study.


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This publication reveals long-term follow-up of 34 patients initially randomized to a study exploring two different cyclosporine-lowering approaches in reducing the progression of renal dysfunction in heart transplant recipients.  Cyclosporine trough levels remained stable in both arms and were significantly lower in the everolimus arm at all time-points. Proteinuria increased significantly during the first 12 […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

Three-Year Outcomes from BENEFIT, a Randomized, Active-Controlled, Parallel-Group Study in Adult Kidney Transplant Recipients


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BENEFIT is a randomized controlled trial comparing two different doses of belatacept, a costimulatory blocker, to standard therapy with cyclosporine in de novo kidney transplant patients. Earlier results from this study showed a higher acute rejection rate with belatacept. Nonetheless, at three years, renal function was significantly better in belatacept-treated patents.

No Comments Posted in Renal Transplantation