Posts Tagged ‘cytomegalovirus’

January 28, 2013

Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study.


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Late CMV disease occurring after prophylaxis is a significant issue in CMV mismatched transplant recipients and predicting which patients will develop late CMV disease is difficult. In the last few years, immune monitoring has gained significant importance in the management of CMV. In this multicenter, prospective cohort study, the authors followed 127 D+/R- transplant patients […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

The Time Course of Development and Impact From Viral Resistance Against Ganciclovir in Cytomegalovirus Infection.


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The authors conducted a study of ganciclovir resistant mutations (GRM) of the UL97 gene in a cohort of 99 SOT recipients who were diagnosed with a first episode of CMV infection. GRMs were defined as ‘signature’ if the mutant/wildtype ganciclovir IC50 ratio was >2 and ‘polymorphic’ if this ratio was

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study.


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Late CMV disease occurring after prophylaxis is a significant issue in CMV mismatched transplant recipients and predicting which patients will develop late CMV disease is difficult. In the last few years, immune monitoring has gained significant importance in the management of CMV. In this multicenter, prospective cohort study, the authors followed 127 D+/R- transplant patients […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

The Time Course of Development and Impact From Viral Resistance Against Ganciclovir in Cytomegalovirus Infection.


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The authors conducted a study of ganciclovir resistant mutations (GRM) of the UL97 gene in a cohort of 99 SOT recipients who were diagnosed with a first episode of CMV infection. GRMs were defined as ‘signature’ if the mutant/wildtype ganciclovir IC50 ratio was >2 and ‘polymorphic’ if this ratio was

No Comments Posted in Transplant Infectious Disease
July 9, 2012

Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation


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Innate immune responses have not been well studied in the context of CMV replication. TLR2, a cell surface pattern recognition receptor, recognizes the CMV envelope glycoprotein. This study examined a large cohort of liver transplant patients that were typed for a known single nucleotide polymorphism in the TLR2 receptor. 11% of patients had 1 or […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
July 9, 2012

Cytomegalovirus Replication Kinetics in Solid Organ Transplant Recipients Managed by Preemptive Therapy


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Many transplant centers use CMV prophylaxis in CMV mismatched patients. However, this study examined a large cohort of CMV D+/R- or R+ liver and kidney patients who were all managed with pre-emptive therapy. CMV syndrome occurred in approximately one-third of transplant patients that were D+/R- and in a greater proportion of those who had liver […]

No Comments Posted in Transplant Infectious Disease
July 9, 2012

Importance of the cytomegalovirus seropositive recipient as a contributor to disease burden after solid organ transplantation


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The incidence of cytomegalovirus (CMV) syndrome after adult solid organ transplantation continues to be a health care burden. In this retrospective analysis of solid organ transplants from 12 UK centreês, patients were followed for two years for the occurrence of CMV disease. The authors present their results comparing the probability of CMV viremia among intermediate […]

No Comments Posted in Transplant Infectious Disease
April 14, 2012

Association of Cytomegalovirus Infection and Disease With Recurrent Hepatitis C After Liver Transplantation.


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CMV infection post-transplant is responsible for direct end-organ disease but may also contribute to other infections through its immunomodulatory properties. Previous studies do not show a consistent link between CMV and recurrence of hepatitis C post-liver transplant. In this retrospective study, CMV infection was associated with an increased fibrosis and inflammation scores. This was regardless […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
February 23, 2012

Clinical utility of molecular surveillance for cytomegalovirus after antiviral prophylaxis in high-risk solid organ transplant recipients.


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Late CMV disease is common after the discontinuation of prophylaxis especially in the high-risk CMV D+/R- group.  Transplant centers take various approaches to detect CMV disease and these include prolonging prophylaxis, doing weekly CMV viral load monitoring, or observing for symptoms.  In this single-center review, 71 high-risk patients received 3 months of antiviral prophylaxis followed […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Virologic and Immunologic Monitoring of Cytomegalovirus to Guide Preemptive Therapy in Solid-Organ Transplantation


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There is increasing literature on immunologic monitoring for cytomegalovirus (CMV) post-transplant in order to guide antiviral therapy.  Assays used for immune monitoring include the Quantiferon-CMV, ELISpot, and flow cytometry-based quantitation of CMV-specific T-cells.  In this study, 134 SOT patients had immunologic monitoring by flow cytometry as well as CMV viral loads.  At 1 year after […]

No Comments Posted in Transplant Infectious Disease