Posts Tagged ‘cytomegalovirus’

October 1, 2011

Association of Cytomegalovirus Infection and Disease With Death and Graft Loss After Liver Transplant in High-Risk Recipients


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In the transplant literature, data associating CMV with rejection and mortality are conflicting.  In this retrospective cohort of 227 CMV D+/R- liver transplant recipients, the authors used a combined endpoint of graft loss or death.  CMV infection and disease was reported in 40% and 19% of patients respectively within one year of transplant; this is […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
October 1, 2011

Incidence and impact of herpes simplex and cytomegalovirus detection in the respiratory tract after lung transplantation


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Herpesvirus reactivations are common in immunosuppressed patients and are associated with increased morbidity and mortality.  This prospective cohort study examined the incidence and clinical impact of HSV and CMV detection in the respiratory tracts of lung transplantation recipients during their post-transplant hospital stay – a period when immunosuppression is highest and patients may be more […]

No Comments Posted in Lung Transplantation
June 18, 2011

Polyfunctional Cytomegalovirus-Specific Immunity in Lung Transplant Recipients Receiving Valganciclovir Prophylaxis


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Extending the duration of CMV prophylaxis in lung transplant patients at risk of CMV can prevent disease, but a concern is potential prevention or reduction of CMV-specific immunity.  In this pilot study, development of CMV-specific immunity in recipients receiving extended antiviral prophylaxis with valganciclovirfor a median of 6 months post-transplant was compared to recipients not […]

No Comments Posted in Lung Transplantation, Transplant Infectious Disease