Posts Tagged ‘delayed graft function’

June 21, 2013

Renal Transplantation After Ex Vivo Normothermic Perfusion: The First Clinical Study


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The standard method of kidney preservation uses an acellular solution at low temperatures, either cold storage or with machine perfusion. This article describes an system which adapts cardioplumonary bypass technology to perfuse the kidney with a oxygenated blood prior to implantation. In this uncontrolled study, kidneys that underwent ex vivo normothermic perfusion had a low […]

No Comments Posted in Renal Transplantation
April 1, 2013

The Impact of Meeting Donor Management Goals on the Development of Delayed Graft Function in Kidney Transplant Recipients


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Even prior to transplant, management of the donor can affect the quality of organs and impact outcomes. This study evaluated the effect of meeting a set of pre-specified goals for donors, such as mean arterial pressure, central venous pressure, urine output and others. Meeting seven of the goals was associated with a lower risk of […]

No Comments Posted in Renal Transplantation
July 9, 2012

Randomized Trial of Short-Course High-Dose Erythropoietin in Donation After Cardiac Death Kidney Transplant Recipients


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Donation after cardiac death (DCD) donors have become an important source of organs, but the rates of delayed graft function (DGF) remains high. Erythropoietin may protect against schema-reperfusion injury. In this randomized controlled trial, erythropoietin or placebo was given to recipients of DCD kidneys. There was no difference in DGF rates, acute rejection, or renal […]

No Comments Posted in Renal Transplantation
April 14, 2012

Preservation Solutions for Static Cold Storage of Kidney Allografts: A Systematic Review and Meta-Analysis


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Optimal outcomes for kidney transplants require excellent preservation of the kidney between the time of procurement and implantation. These authors performed a meta-analysis of studies comparing different preservation solutions in use today. While the number of available studies was small, Eurocollins solution was associated with a higher risk of delayed graft failure than UW, HTK, […]

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