Posts Tagged ‘desensitization’

December 19, 2011

Antibody Removal Before ABO-Incompatible Renal Transplantation: How Much Plasma Exchange Is Therapeutic?


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Desensitization protocols to allow for transplantation across the ABO-blood barrier have become accepted in renal transplantation over the last decade. Plasma exchange is a frequent part of these protocols, and physically removes the antibodies from the circulation. This single-centre cohort study looked at the number of plasma exchange sessions required to reach a threshold where […]

No Comments Posted in Renal Transplantation
November 18, 2011

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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The approach to desensitization varies between cardiac transplant centers.  This pilot study by Kobashigawa et al, explores a new approach in desensitization attempts in patients refractory to an IVIg/rituximab combination therapy.  Bortezomib successfully reduced cPRA in the majority of patients with an acknowledged increase risk of infection.

No Comments Posted in Cardiac Transplantation
August 14, 2011

Desensitization in HLA-Incompatible Kidney Recipients and Survival


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Sensitization to HLA antigens results in increased waiting times for a transplant, which is associated with an increased risk of death. The current study examined whether performing living-donor renal transplants following desensitization resulted in a survival benefit when compared to equally sensitized patients on the wait list. A protocol using plasmapheresis and low-dose IVIg was […]

No Comments Posted in Renal Transplantation