Posts Tagged ‘donor-specific antibodies’

August 14, 2011

Current methodologies for detecting sensitization to HLA antigens


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This comprehensive review discusses the progression of tests used for HLA antibody detection over the last 40 years highlighting the limitations of each of the techniques. Much of the discussion is focused on the latest single antigen bead technology including its many advantages, listing of limitations relating to the technology and translation into accurate interpretation […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
August 14, 2011

Desensitization in HLA-Incompatible Kidney Recipients and Survival


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Sensitization to HLA antigens results in increased waiting times for a transplant, which is associated with an increased risk of death. The current study examined whether performing living-donor renal transplants following desensitization resulted in a survival benefit when compared to equally sensitized patients on the wait list. A protocol using plasmapheresis and low-dose IVIg was […]

No Comments Posted in Renal Transplantation
June 18, 2011

Alloimmunity-Induced Autoimmunity as a Potential Mechanism in the Pathogenesis of Chronic Rejection of Human Lung Allografts


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Bronchiolitis obliterans syndrome remains the leading cause of morbidity and mortality after lung transplantation.  This retrospective study shows the development of donor specific antibodies during the period following lung transplantation is correlated to BOS as well as the development of antibodies to self-antigens.  Using a sensitive solid-phase assay to detect DSA, the authors demonstrated 42.7% […]

No Comments Posted in Lung Transplantation