Posts Tagged ‘DSA’

November 28, 2013

Outcomes of Simultaneous Liver and Kidney Transplantation in Relation to a High Level of Preformed Donor-Specific Antibodies


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Liver transplants rarely experience antibody-mediated rejection, and it has been suggested that a liver transplant can protect the kidney if a simultaneous transplant is performed. In this single-center study, patients who received a simultaneous liver-kidney transplant had a higher risk of acute rejection, but similar renal function and patient and graft survival, whether or not […]

No Comments Posted in Liver Transplantation, Renal Transplantation
November 28, 2013

Class II HLA Epitope Matching—A Strategy to Minimize De Novo Donor-Specific Antibody Development and Improve Outcomes


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Although testing for HLA antibodies is long-established practice in transplantation, the immune system actually makes antibodies against specific epitopes, not antigens. This study used the HLA Matchmaker program to assess whether the degree of epitope mismatching predicted the development of post-transplant class II donor-specific antibodies. Thresholds for epitope mismatching at DR and DQ were found. […]

No Comments Posted in Renal Transplantation, Uncategorized
September 26, 2013

Acute Cellular and Antibody-Mediated Rejection of the Pancreas Allograft: Incidence, Risk Factors and Outcomes

Antibody-mediated pancreas transplant rejection is a relatively recently recognized entity. In this retrospective study, the rate of antibody-mediated rejection post-pancreas transplant was similar to that of acute cellular rejection. Class I DSA were more predictive of antibody-mediated rejection than class II DSA. Antibody-mediated rejection should be considered in all patients with pancreas graft dysfunction post-transplant.

No Comments Posted in Pancreas Transplantation, Renal Transplantation
June 21, 2013

Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: A single-center, retrospective study.


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Approximately 10 – 20% of heart transplant recipients will develop AMR. Standardized nomenclature has improved the diagnosis. This single center study revisits the risks of Class I and II DSA to C4D +IF and graft failure. C4d staining correlated better with graft failure in patients with DSA to only Class I or DSA to both […]

No Comments Posted in Cardiac Transplantation
April 1, 2013

Donor-Specific Antibodies to Class II Antigens Are Associated With Accelerated Cardiac Allograft Vasculopathy: A Three-Dimensional Volumetric Intravascular Ultrasound Study.


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This preliminary study from Mayo clinic demonstrated that cardiac transplant patients with preformed class II DSA may be at increased risk for accelerated graft vasculopathy on consecutive 3D IVUS. Although this technology may not be available at all centers, this sstudy provides further weight to the potential clinical impact of class II DSA.

No Comments Posted in Cardiac Transplantation
January 28, 2013

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation


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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation


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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
July 4, 2011

Donor-Directed MHC Class I Antibody Is Preferentially Cleared from Sensitized Recipients of Combined Liver/Kidney Transplants


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Although simultaneous liver and kidney transplantation (SLKT) is uncommon, the liver’s ability to resist hyperacute antibody mediated rejection (AbMR) may allow the transplant to succeed despite the presence of pre-existing donor specific antibody (DSA). However, the long term impact of pre-existing DSA in SLKT is incompletely understood. This study analyzed a small cohort of SLKT […]

No Comments Posted in Liver Transplantation, Renal Transplantation
July 4, 2011

Early and Late Acute Antibody-Mediated Rejection Differ Immunologically and in Response to Proteasome Inhibition


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Antibody-mediated rejection (AbMR) requires the production of donor specific antibody (DSA) by recipient plasma cells and can present at early or late times post-transplant. Bortezomib is a proteasome inhibitor (PI) approved by the FDA for treatment of multiple myeloma that is increasingly being used off-label for the treatment of AbMR. This study, from one of […]

No Comments Posted in Renal Transplantation