Posts Tagged ‘eculizumab’

January 28, 2013

Eculizumab for Atypical Hemolytic Uremic Syndrome Recurrence in Renal Transplantation


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Eculizumab is a monoclonal antibody that prevents complement activation. It has been found to be an effective treatment for atypical hemolytic-uremic syndrome (aHUS). This retrospective study is the largest collection of previously published and unpublished cases to date. Eculizumab was effective at both preventing and treating recurrence of aHUS.

No Comments Posted in Renal Transplantation
January 28, 2013

Eculizumab for Atypical Hemolytic Uremic Syndrome Recurrence in Renal Transplantation


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Eculizumab is a monoclonal antibody that prevents complement activation. It has been found to be an effective treatment for atypical hemolytic-uremic syndrome (aHUS). This retrospective study is the largest collection of previously published and unpublished cases to date. Eculizumab was effective at both preventing and treating recurrence of aHUS.

No Comments Posted in Renal Transplantation
February 23, 2012

Recurrent Dense Deposit Disease After Renal Transplantation: An Emerging Role for Complementary Therapies


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Membranoproliferative glomerulonephritis type II, or dense deposit disease, is a rare type of renal disease caused by excessive complement deposition in the kidney. It is also associated with a high rate of recurrence post-transplant. In this case report, a patient developed recurrent dense deposit disease shortly after transplant. Despite aggressive treatment, renal function worsened and […]

No Comments Posted in Renal Transplantation
November 18, 2011

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients


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There has been much interest in transplantation around eculizumab, a monoclonal antibody that blocks formation of the membrane attack complex of the complement cascade. In this single-centre, non-randomized study, patients with donor-specific antibody who were treated with eculizumab had a significantly lower rate of antibody-mediated rejection that a group of historical controls. There was also […]

No Comments Posted in Renal Transplantation