Posts Tagged ‘focal segmental glomerulosclerosis’

September 1, 2013

Podocyte Effacement Closely Links to suPAR Levels at Time of Posttransplantation Focal Segmental Glomerulosclerosis Occurrence and Improves With Therapy


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Serum soluble urokinase-type plasminogen activator receptor (suPAR) has been put forth as the a candidate for the elusive “FSGS” factor that may lead to aggressive and early recurrence post-transplant. This study of patients with recurrent FSGS post-transplant found higher suPAR levels in patients with more extensive podocyte damage on renal biopsy. However, this study is […]

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October 1, 2011

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis


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Recurrence of focal segmental glomerulosclerosis (FSGS) post-transplant can be dramatic and lead to graft loss. Several years ago, a “permeability factor” was discovered that seemed to cause recurrence, and could be removed by plasma exchange. However, until now, the nature of this factor has been unknown. In this set of experiments, the authors show that […]

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