Posts Tagged ‘generic’

January 28, 2013

Conversion From Twice-Daily Tacrolimus to Once-Daily Extended Release Tacrolimus (LCPT): The Phase III Randomized MELT Trial


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Advagraf, a once-daily extended-release tacrolimus formulation was released several years ago. Another once daily formulation of tacrolimus called LCPT, has now been developed. In this non-inferiority RCT, the LCPT formulation showed similar outcomes to standard twice-daily tacrolimus with a lower daily dose. The availability of multiple once-daily tacrolimus formulations, as well as several generic versions […]

No Comments Posted in Renal Transplantation
January 28, 2013

Conversion From Twice-Daily Tacrolimus to Once-Daily Extended Release Tacrolimus (LCPT): The Phase III Randomized MELT Trial


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Advagraf, a once-daily extended-release tacrolimus formulation was released several years ago. Another once daily formulation of tacrolimus called LCPT, has now been developed. In this non-inferiority RCT, the LCPT formulation showed similar outcomes to standard twice-daily tacrolimus with a lower daily dose. The availability of multiple once-daily tacrolimus formulations, as well as several generic versions […]

No Comments Posted in Renal Transplantation
February 23, 2012

Generic Immunosuppression in Solid Organ Transplantation: A Canadian Perspective


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Over the next few years, patents on all of the currently used oral immunosuppressive medications will expire. There is concern within the transplant community as to whether generic immunosuppressive medications are truly as safe and effective as the original, brand-name versions. In this paper, the evidence comparing brand-name to generic immunosuppressants in transplantation is reviewed, […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation