Posts Tagged ‘graft failure’

April 1, 2013

Health-Related Quality of Life and Long-Term Survival and Graft Failure in Kidney Transplantation: A 12-Year Follow-Up Study


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Long-term survival for kidney transplant continues to show variability. This study examined whether health-related quality of life (HRQOL) predicts long-term mortality in kidney transplantation after adjustment for known risk factors. A cohort of 347 kidney transplant recipients was followed up for 12 years after enrolment. They completed measures of HRQOL and medical records were reviewed […]

No Comments Posted in Renal Transplantation
January 28, 2013

Reduced survival and quality of life following return to dialysis after transplant failure: the Dialysis Outcomes and Practice Patterns Study


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The transition from a functioning renal transplant to dialysis has been recognized as a high-risk period. In this study using data from the multinational DOPPS study, patients with a failed renal transplant had worse outcomes than wait-listed dialysis patients. A major cause of death among patients with a failed graft was infection.

No Comments Posted in Renal Transplantation
January 28, 2013

Reduced survival and quality of life following return to dialysis after transplant failure: the Dialysis Outcomes and Practice Patterns Study


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The transition from a functioning renal transplant to dialysis has been recognized as a high-risk period. In this study using data from the multinational DOPPS study, patients with a failed renal transplant had worse outcomes than wait-listed dialysis patients. A major cause of death among patients with a failed graft was infection.

No Comments Posted in Renal Transplantation
October 30, 2012

Donor-Specific Antibodies after Ceasing Immunosuppressive Therapy, with or without an Allograft Nephrectomy


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The best strategy to manage patients with a failed renal allograft is unknown. It is unknown whether the allograft acts a “sponge” for DSA, and removal may lead to higher levels of anti-HLA antibodies. This study compared patients whose immunosuppression stopped, and who either underwent a graft nephrectomy or not. Allograft nephrectomy resulted in a […]

No Comments Posted in Renal Transplantation
April 14, 2012

Identifying Recipients at High Risk for Graft Failure After Heart Retransplantation.


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A lack of donor organs continues to plague the transplant community.  Retransplantation in this setting can be controversial and requires cautious selection of recipients. This study reviewed the UNOS database for factors which could potentially serve as relative contraindications to heart retransplantation.  In contrast to other studies, acute need for retransplantation, primary graft failure and […]

No Comments Posted in Cardiac Transplantation
December 19, 2011

Association of Pretransplant Serum Phosphorus with Posttransplant Outcomes


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Both hypo- and hyperphosphatemia are associated with an increased risk of death in dialysis patients. In this large registry study, severe hyperphosphatemia was associated with increased risk of death. More moderate hyperphosphatemia was associated with graft failure after kidney transplantation. This shows the importance of phosphate management in patients pre-transplant, as it will affect post-transplant […]

No Comments Posted in Renal Transplantation
July 4, 2011

Graft Failure and Adaptation Period to Adult Healthcare Centers in Pediatric Renal Transplant Patients


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Transition from pediatric to adult care can be difficult for patients and challenging for health care teams. This may lead to adverse events. In this registry study, the risk of graft failure was significantly higher during the period around transfer to adult care than in the period beforehand.

No Comments Posted in Renal Transplantation
July 4, 2011

Solid Organ Allograft Survival Improvement in the United States: The Long-Term Does Not Mirror the Dramatic Short-Term Success


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This article reviews registry outcomes of heart, liver, lung, pancreas and intestine transplantation in the United States over a twenty-year period. While one-year graft survival and first-year attrition rates have made considerable progress over this time, attrition rates over the long-term have shown little improvement. This highlights the need to focus efforts on the causes […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation