Posts Tagged ‘graft survival’

October 11, 2013

Complement-binding anti-HLA antibodies and kidney-allograft survival


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The study by Loupy et. al. shows an important role for complement-fixing (C1Q+) donor-specific HLA antibodies (DSA) in risk prediction of kidney allograft loss. The study examined 1016 kidney transplant recipients transplanted across negative T- and B-cell cytotoxic crossmatches with subsequent testing by Luminex single antigen beads for the detection of complement-fixing as well as […]

No Comments Posted in Renal Transplantation
February 23, 2012

Posttransplant Donor-Specific Anti-HLA Antibodies Negatively Impact Pancreas Transplantation Outcome


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Continuing on with other recent developments related to antibody-mediated rejection of pancreas transplants, the current study reinforces the strong effect of donor-specific antibodies (DSA) on graft survival in simultaneous pancreas-kidney transplant patients. A total of 167 pancreas transplants (152 pancreas-kidney) were followed for the  development of HLA antibodies and DSA during 9 years of follow-up. […]

No Comments Posted in Pancreas Transplantation
August 14, 2011

Outcomes of adult living donor liver transplantation: Comparison of the adult-to-adult living donor liver transplantation cohort study and the national experience


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This article defines risk factors for patient mortality and graft loss in living-donor liver transplantation (LDLT) in North American centers. It analyzes the association between the center’s experience and the outcomes. It provide guidance for selection of donors and recipients in adult living-donor liver transplantation.

No Comments Posted in Liver Transplantation
July 4, 2011

Living Donor Age and Kidney Transplant Outcomes


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This large single-center study examined the effect of living-donor age on the outcomes of renal transplantation. Living-donor kidneys from older donors were associated with a higher incidence of post-transplant proteinuria. The relationship between living-donor age and long-term graft survival was also more significant for younger, but not older recipients.

No Comments Posted in Renal Transplantation
July 4, 2011

Solid Organ Allograft Survival Improvement in the United States: The Long-Term Does Not Mirror the Dramatic Short-Term Success


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This article reviews registry outcomes of heart, liver, lung, pancreas and intestine transplantation in the United States over a twenty-year period. While one-year graft survival and first-year attrition rates have made considerable progress over this time, attrition rates over the long-term have shown little improvement. This highlights the need to focus efforts on the causes […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation