Posts Tagged ‘heart transplant’

October 6, 2013

The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report—2013; Focus Theme: Age


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The 30th adult heart transplant ISHLT report is based on data submitted on 110,486 heart transplants in recipients of all ages (including 99,008 adults) by 407 centers worldwide since 1982 through June 30, 2012, with follow-up until June 30, 2012.

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September 9, 2013

Is it time for a cardiac allocation score? First results from the Eurotransplant pilot study on a survival benefit based heart allocation


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The Eurotransplant group demonstrated mortality on the waitlist could be predicted for non-VAD critically ill (high urgency or urgent request) patients using the Heart Failure Survival Score (HFSS) and the Seattle Heart Failure Model (SHFM). The Index for Mortality Prediction After Cardiac Transplantation (IMPACT) score was successful for predicting mortality post transplant in non-VAD patients. […]

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September 8, 2013

The urgent priority for transplantation is to trim the waiting list


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This thought provoking editorial by Dr. Lynne Warner Stevenson provides commentary on ineffective waitlist strategies and the need for change.

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September 7, 2013

Heart transplantation outcomes from cardiac arrest-resuscitated donors.


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CPR requiring donors, utilized and identified in the UNOS database tended to be younger and had a mean CPR time of 20 minutes. Despite resucitation times, use of carefully selected donors requiring CPR did not impact recipient outcomes including patient and graft survival. The authors hypothesize that ischemic preconditioning may influence the non-inferior outcomes.

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September 2, 2013

Influence of Race/Ethnic Differences in Pre-Transplant Panel Reactive Antibody on Outcomes in Heart Transplant Recipients.


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Racial and ethnic differences in long-term survival after HT are well recognized. This US study demonstrated that after adjusting for BMI, blood type, sensitization, presence of VAD at transplant, and region, both Black and Hispanic race/ethnicity ( β=0.046, p

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July 10, 2013

A cardioprotective preservation strategy employing ex vivo heart perfusion facilitates successful transplant of donor hearts after cardiocirculatory death.


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Various techniques are being explored to optimize hearts and the assess organ function before transplantation. This may ultimately increase the number of organs available for transplantation. In this experimental model of DCD, an ex vivo heart perfusion strategy using initial reperfusion with a tepid adenosine-lidocaine cardioplegia and continuous myocardial perfusion minimized myocardial injury and improved […]

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July 9, 2013

Prophylactic implantable cardioverter defibrillator treatment in patients with end-stage heart failure awaiting heart transplantation.


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This observational study supports the CCS recommendations of ICD consideration in transplant eligible patients. In this study, ICDs appear to be associated with a reduction in all-cause mortality in both primary and secondary prevention compared to those without an ICD despite a median time on the waiting list of only 8 months (estimated 1-year: 88±3% vs […]

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June 21, 2013

Advanced Therapies for Congenital Heart Disease: Ventricular Assist Devices and Heart Transplantation.


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This article reviews heart transplant and mechanical circulatory support approaches and outcomes in the management of congenital heart disease; a growing demographic in the adult heart transplant community.

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June 21, 2013

Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial.


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This multicenter trial randomized de novo heart transplant recipients to everolimus 1.5 mg or 3.0 mg with reduced-dose cyclosporine, or mycophenolate mofetil (MMF) 3 g/day with standard-dose cyclosporine (plus corticosteroids ± induction). Primary efficacy endpoint was the 12-month composite incidence of biopsy-proven acute rejection, acute rejection associated with hemodynamic compromise, graft loss/retransplant, death or loss […]

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June 21, 2013

Everolimus immunosuppression in de novo heart transplant recipients: What does the evidence tell us now?


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This review article analyzes the currently available data supporting the use of everolimus in de novo heart transplant patients. Rejection, renal function, malignancy, infection and wound complications including pleural and pericardial effusions are examined. The evidence suggests that the most convincing reasons for use of everolimus are to slow the progression of CAV and to […]

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