Posts Tagged ‘heart transplant’

June 21, 2013

Cost-Effectiveness of Ventricular Assist Device Therapy as a Bridge to Transplant in Comparison to Non-Bridged Cardiac Recipients.


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This article provides contemporary Canadian data for the cost-effectiveness of BTT-VAD versus unbridged HTx recipients. The sensitivity analysis estimated a 59%, 54% and 43% chance of BTT-VAD therapy being cost-effective for high, medium and low risk patients at a willingness to pay of $100,000/LY.

No Comments Posted in Cardiac Transplantation
June 21, 2013

Simultaneous Thoracic and Abdominal Transplantation: Can We Justify Two Organs for One Recipient?


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This paper reviews the outcomes documented in the UNOS database for recipients of simulataneous thoracic and abdominal transplants. An interesting ethical discussion concludes the article.

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 21, 2013

Characterization of 25+ year survivors of cardiac transplantation


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This single center study reviews the echocardiographic, hemodynamic and clinical characteristics of long-term survivors post heart transplant. The investigators demonstrated a significant burden of cardiac allograft vasculopathy in the setting of preserved graft function. Diastolic parameters were significantly altered.

No Comments Posted in Cardiac Transplantation
June 21, 2013

Long-term outcome in patients treated with combined heart and liver transplantation for familial amyloidotic cardiomyopathy


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Currently, adults with congenital heart disease account for 3% of heart and nearly 40% of heart_lung transplant recipients worldwide. Ten years of patient outcomes were reviewed between 2001 and 2011. This single center, high volume center demonstrated comparable early and mid-term outcomes in adult congenital heart patients to general outcomes when careful recipient selection was […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

A Prospective, Multicenter Study of Ventricular Assist Device Infections


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This prospective study demonstrated that the incidence of ventricular assist device related infection continues to burden approximately 20% of implanted patients in the era of smaller continuous flow devices. There was an associated increase in one year mortality.

No Comments Posted in Cardiac Transplantation
June 21, 2013

Everolimus Versus Mycophenolate Mofetil in Heart Transplantation: A Randomized, Multicenter Trial.


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This multicenter, randomized controlled trial assessed the efficacy, safety and incidence of CAV in de novo heart transplant patients receiving everolimus at two doses (1.5 mg/day or 3.0 mg/day in divided doses) with reduced-dose cyclosporine versus MMF with full-dose cyclosporine. The high dose everolimus group was terminated due to increased mortality. The lower dose everolimus […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Preoperative Assessment of High Risk Candidates to Predict Survival Following Heart Transplantation.


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Alternative wait list strategies for heart transplant recipients have not yet been popularized in Canada. This article from Columbia University explores the concept of matching ñhigh riskî recipients with marginal donor organs. Survival analysis revealed lower post-HTx survival in high risk recipients (82.2 versus 87.4 % at 1-yr; 59.8 versus 76.3 % at 5-yrs post-HTx; […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: A single-center, retrospective study.


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Approximately 10 – 20% of heart transplant recipients will develop AMR. Standardized nomenclature has improved the diagnosis. This single center study revisits the risks of Class I and II DSA to C4D +IF and graft failure. C4d staining correlated better with graft failure in patients with DSA to only Class I or DSA to both […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Differential Effect of Everolimus on Progression of Early and Late Cardiac Allograft Vasculopathy in Current Clinical Practice.


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CAV remains the leading cause of long-term death in heart transplant recipients. This retrospective analysis of prospectively collected data (IVUS) demonstrated everolimus independently reduced the odds for early CAV (0.14 [0.01_0.77]; p 0.02) but it did not appear to influence late CAV progression. High dose statin use was favorably associated with a reduction in both […]

No Comments Posted in Cardiac Transplantation
January 28, 2013

Effects of chronic sildenafil use on pulmonary hemodynamics and clinical outcomes in heart transplantation.


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This retrospective study originating from the Laval group demonstrated that peri-heart transplant sildenafil therapy was well tolerated and decreased MPAP, PVR, and TPG in patients with fixed secondary pulmonary hypertension in the absence of ventricular assist device support. Excellent early and late survival comparable to patients without significant pulmonary hypertension was demonstrated. Duration of therapy […]

1 Comment Posted in Cardiac Transplantation