Posts Tagged ‘heart transplantation’

August 17, 2012

Bosentan in heart transplantation candidates with severe pulmonary hypertension: efficacy, safety and outcome after transplantation.


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Bosentan is an orally administered dual endothelin-receptor antagonist that has proven effective in therapy for pulmonary arterial hypertension (PAH). Severe PAH as confirmed by increased pulmonary vascular resistance (PVR), is associated with increased right ventricular failure and mortality after heart transplantation. In this prospective study, the authors administered bosentan to patients considered high-risk candidates for […]

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August 17, 2012

Should Patients 60 Years and Older Undergo Bridge to Transplantation With Continuous-Flow Left Ventricular Assist Devices?


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The use of continuous-flow left ventricular assist devices (LVADs) as a bridge to transplantation (BTT) has become a common practice. In this single-centre retrospective analysis, the authors looked into outcomes of continuous-flow LVADs as BTT as compared to direct transplantation and inotrope as BTT in patients over the age of 60 years. Their findings suggest […]

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February 23, 2012

Allosensitization and outcomes in pediatric heart transplantation


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Allosensitization of pediatric heart transplant candidates continues to be a problem with uncertainty on the best clinical approach to manage these patients. Using data from the Pediatric Heart Transplant Study, the current study examined >3000 patients listed for heart transplantation of which 2237 were transplanted with available panel reactive antibody (PRA) data. The outcomes for […]

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February 23, 2012

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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HLA antibodies produced by plasma cells are a major barrier for patients awaiting heart transplantation due to increased wait list time, increased risk of rejection post-transplant, and decreased survival. Proteasome inhibition using bortezomib can lead to plasma cell apoptosis and potentially decrease antibody production. As already shown in renal transplants where bortezomib decreases antibody production […]

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December 19, 2011

Factors associated with work status at 5 and 10 years after heart transplantation.


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The authors sought to study factors that influence work status over the long term after heart transplantation at 4 US transplant centres. They utilized a range of instruments to ascertain clinical, health status, and demographic factors that predicted those who work and did not work at 5 and 10 years post-transplant. Their sample was predominately […]

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