Posts Tagged ‘hepatitis C’

June 21, 2013

Optimal Testing of the Live Organ Donor for Blood-Borne Viral Pathogens: The Report of a Consensus Conference


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Transmission of infection from donor to recipient is an an inherent risk in transplantation that can likely never be completely eliminated. This is true even in living donation, where transmission of hepatitis C and HIV has been reported. This paper reports the results of a conference on this topic. Most significant is the fact that […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease, Uncategorized
July 9, 2012

Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study


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The life expectancy of HIV positive persons has improved considerably in the past decade. Several countries are now performing kidney and liver transplants in HIV infected recipients. One of the leading indications for liver transplant in HIV patients is Hepatitis C. This study from Spain examines whether outcomes are similar in HCV/HIV coinfected patients as […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
April 14, 2012

Association of Cytomegalovirus Infection and Disease With Recurrent Hepatitis C After Liver Transplantation.


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CMV infection post-transplant is responsible for direct end-organ disease but may also contribute to other infections through its immunomodulatory properties. Previous studies do not show a consistent link between CMV and recurrence of hepatitis C post-liver transplant. In this retrospective study, CMV infection was associated with an increased fibrosis and inflammation scores. This was regardless […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
November 18, 2011

Limiting Hepatitis C Virus Progression in Liver Transplant Recipients Using Sirolimus-Based Immunosuppression


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Hepatitis C recurrence following liver transplantation is universal, and it is one of the main reasons for inferior outcomes in this population. Sirolimus, which has antifibrotic properties, reduces progression of liver fibrosis in animal models. In this single-centre, retrospective study, liver transplant recipients initially treated with sirolimus showed less progression of fibrosis on surveillance biopsies […]

No Comments Posted in Liver Transplantation
October 1, 2011

Impact of Hepatitis C Virus Infection on the Risk of Infectious Complications After Kidney Transplantation: Data From the RESITRA/REIPI Cohort


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RESITRA/REIPI is a Spanish Network for Research in Transplantation that has previously conducted robust studies of post-transplant infections.  In this prospective analysis, the authors compared infectious complications between 1302 kidney transplant patients that were HCV positive (n=105) vs. HCV negative.  There was no difference in the overall incidence of infections; however, HCV positive patients had […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
July 4, 2011

Major Challenges Limiting Liver Transplantation in the United States.


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This review analyzes the current challenges of liver transplantation given the discrepancy between the number of donors and patients on the waiting list. It discusses new areas of investigation that address some of these issues, such as expanding the donor pool, treatment of recurrent hepatitis C post-transplant and early detection of hepatocellular carcinoma, with appropriate […]

No Comments Posted in Liver Transplantation
July 4, 2011

Effect of Kidney Transplantation on Outcomes among Patients with Hepatitis C


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Patients with hepatitis C need to be carefully evaluated before renal transplantation, due to concerns that they liver disease may progress more rapidly after transplant and lead to liver failure. In this single-center study of hepatitis C-infected patients, liver biopsy data both before transplant, on the wait list and after transplant were available. Kidney transplantation […]

No Comments Posted in Renal Transplantation