Posts Tagged ‘hepatocellular carcinoma’

August 17, 2012

A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list


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Hepatocellular carcinoma (HCC) has become one of the main indications for liver transplantation. With time, it appears that patients with HCC have easier access to transplantation than non-HCC patients due to the exception points they receive. The authors used a comparative risk model assessment of HCC vs non-HCC on the waiting list to look at […]

No Comments Posted in Liver Transplantation
February 23, 2012

Critical review of controversial issues in the management of advanced pediatric liver tumours


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Hepatoblastoma and hepatocellular carcinoma are the most common primary hepatic tumors in children.  To date, treatment is not standardized, and outcomes from large patient cohorts are not well documented.  The management of children with locally advanced, unresectable disease or those with extra-hepatic distant metastases is often complex and challenging for multidisciplinary teams comprised of pediatric […]

No Comments Posted in Liver Transplantation
November 18, 2011

Should we use living donor grafts for patients with hepatocellular carcinoma? Ethical considerations


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The paper examines whether living donor grafts for patients with hepatocellular carcinoma should even be used, and whether the same criteria that apply to deceased donor liver transplantation (DDLT) allocation (Milan and UCSF criteria) are applicable in this situation.  The authors explain that DDLT is governed by justice and utility concerns, but that living donor […]

No Comments Posted in Liver Transplantation
November 18, 2011

MELD Exceptions and Rates of Waiting List Outcomes


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In this manuscript the authors examined the impact of MELD exception points. This is mostly commonly given to patients with hepatocellular carcinoma (HCC) who are on the waiting list. Liver transplantation for HCC continues to rise and in some centers approaches 30% of the waiting list. By awarding exception points, patients who are listed with […]

No Comments Posted in Liver Transplantation
October 1, 2011

Can the dropout risk of candidates with hepatocellular carcinoma predict survival after liver transplantation?


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The allocation rules for liver transplant candidates with HCC are difficult issues and in continuous evolution. In this study the authors analyze factors affecting dropout risk and post-liver transplant survival in HCC recipients, using a previous validated HCC priority score.  This will help to identify patients with good and poor outcomes.  

No Comments Posted in Liver Transplantation
October 1, 2011

Is surgical resection superior to transplantation in the treatment of hepatocellular carcinoma?


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Hepatocellular carcinoma (HCC) has been estimated to be the third most common cause of cancer-related death. The best potential curative therapies available are liver resection or transplantation. Determination of which curative intent therapy to offer to which patient remains poorly defined. In this analysis the authors define the relative outcomes for patients who theoretically might […]

No Comments Posted in Liver Transplantation
August 14, 2011

2010 consensus conference on liver transplantation for HCC: Should we use living donor grafts for patients with hepatocellular carcinoma (HCC)?


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This article examines the ethical considerations around using living donors for liver transplantation for recipients with hepatocellular carcinoma. The authors summarize the discussion and recommendations of a 2010 consensus conference on this issue and answer three questions:  Why is live donation necessary at all and is it different for patients with HCC? What is double […]

No Comments Posted in Liver Transplantation
July 4, 2011

Comparison of radio-frequency ablation and trans-arterial chemoembolization for hepatocellular carcinoma within the Milan criteria: A propensity score analysis


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The number of liver transplants for hepatocellular carcinoma (HCC) is significantly increasing. Several modalities have been described for the treatment of HCC including radiofrequency ablation (RFA) and trans-arterial chemoembolization (TACE). These modalities can be used as a bridge to liver transplant, or a final treatment in and of themselves.  In this single-center retrospective study, the […]

No Comments Posted in Liver Transplantation
July 4, 2011

Major Challenges Limiting Liver Transplantation in the United States.


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This review analyzes the current challenges of liver transplantation given the discrepancy between the number of donors and patients on the waiting list. It discusses new areas of investigation that address some of these issues, such as expanding the donor pool, treatment of recurrent hepatitis C post-transplant and early detection of hepatocellular carcinoma, with appropriate […]

No Comments Posted in Liver Transplantation