Posts Tagged ‘HLA’

November 28, 2013

Outcomes of Simultaneous Liver and Kidney Transplantation in Relation to a High Level of Preformed Donor-Specific Antibodies


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Liver transplants rarely experience antibody-mediated rejection, and it has been suggested that a liver transplant can protect the kidney if a simultaneous transplant is performed. In this single-center study, patients who received a simultaneous liver-kidney transplant had a higher risk of acute rejection, but similar renal function and patient and graft survival, whether or not […]

No Comments Posted in Liver Transplantation, Renal Transplantation
November 28, 2013

Class II HLA Epitope Matching—A Strategy to Minimize De Novo Donor-Specific Antibody Development and Improve Outcomes


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Although testing for HLA antibodies is long-established practice in transplantation, the immune system actually makes antibodies against specific epitopes, not antigens. This study used the HLA Matchmaker program to assess whether the degree of epitope mismatching predicted the development of post-transplant class II donor-specific antibodies. Thresholds for epitope mismatching at DR and DQ were found. […]

No Comments Posted in Renal Transplantation, Uncategorized
September 26, 2013

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival


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The ability to detect anti-HLA antibodies is very sensitive and specific, but it is not clear if all antibodies are the same. Specifically, some antibodies may bind and activate complement better than others. In this retrospective study, the presence of antibodies that could fix C1q and initiate the complement cascade was associated with higher rates […]

No Comments Posted in Renal Transplantation, Uncategorized
September 2, 2013

Influence of Race/Ethnic Differences in Pre-Transplant Panel Reactive Antibody on Outcomes in Heart Transplant Recipients.


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Racial and ethnic differences in long-term survival after HT are well recognized. This US study demonstrated that after adjusting for BMI, blood type, sensitization, presence of VAD at transplant, and region, both Black and Hispanic race/ethnicity ( β=0.046, p

No Comments Posted in Cardiac Transplantation
August 31, 2013

Higher Risk of Kidney Graft Failure in the Presence of Anti-Angiotensin II Type-1 Receptor Antibodies


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While HLA antibodies are a well-recognized risk factor for graft loss, the role of non-HLA antibodies is less clear. Antibodies to angiotensin II type I receptor has been previously reported in patients with failing grafts. In this study, patients who developed anti-AT I receptor antibodies had a higher risk of graft failure over and above […]

No Comments Posted in Renal Transplantation, Uncategorized
June 21, 2013

Advanced Therapies for Congenital Heart Disease: Ventricular Assist Devices and Heart Transplantation.


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This article reviews heart transplant and mechanical circulatory support approaches and outcomes in the management of congenital heart disease; a growing demographic in the adult heart transplant community.

No Comments Posted in Cardiac Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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Preventing the development of anti-HLA antibodies is an important step in improving access to transplantation. In this non-randomized retrospective study, patients who received red blood cell transfusions from donors who were closely matched for class I antigens were less likely to develop anti-HLA antibodies than patients who received randomly selected donors. These findings are intriguing, […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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Preventing the development of anti-HLA antibodies is an important step in improving access to transplantation. In this non-randomized retrospective study, patients who received red blood cell transfusions from donors who were closely matched for class I antigens were less likely to develop anti-HLA antibodies than patients who received randomly selected donors. These findings are intriguing, […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation