Posts Tagged ‘HLA antibodies’

January 28, 2013

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation


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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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HLA sensitization in the pre-transplant period can limit the chances of successfully receiving a transplant. Sensitization (primarily to mismatched HLA class I) can occur as a result of blood transfusions due to the presence of platelets in each unit of blood and the small number of leukocytes that remain even in leuko-depleted blood. This study […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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HLA sensitization in the pre-transplant period can limit the chances of successfully receiving a transplant. Sensitization (primarily to mismatched HLA class I) can occur as a result of blood transfusions due to the presence of platelets in each unit of blood and the small number of leukocytes that remain even in leuko-depleted blood. This study […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation


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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
May 23, 2012

Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy


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Experience with proteasome inhibitors (PI) for treating antibody-mediated rejection (ABMR) and HLA antibody removal is increasing. However, the durability of the effects PI on HLA antibody removal is unknown. This study examines this question from a unique point of view due to the use of the PI bortezomib as either a combination therapy or a […]

No Comments Posted in Renal Transplantation
April 14, 2012

Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy


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Experience with proteasome inhibitors (PI) for treating antibody-mediated rejection (ABMR) and HLA antibody removal is increasing. However, the durability of the effects PI on HLA antibody removal is unknown. This study examines this question from a unique point of view due to the use of the PI bortezomib as either a combination therapy or a […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
February 23, 2012

Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients


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Antibody-mediated rejection (ABMR)in the presence of high levels of donor-specific antibodies (DSA) likely involves complement activation as part of the mechanism of graft damage. This study examined the efficacy of inhibiting complement activation by neutralizing C5 with a humanized anti-C5 antibody; eculizumab. The effect of anti-C5 treatment was assessed in 26 highly sensitized recipients of […]

No Comments Posted in Renal Transplantation
February 23, 2012

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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HLA antibodies produced by plasma cells are a major barrier for patients awaiting heart transplantation due to increased wait list time, increased risk of rejection post-transplant, and decreased survival. Proteasome inhibition using bortezomib can lead to plasma cell apoptosis and potentially decrease antibody production. As already shown in renal transplants where bortezomib decreases antibody production […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

Posttransplant Donor-Specific Anti-HLA Antibodies Negatively Impact Pancreas Transplantation Outcome


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Continuing on with other recent developments related to antibody-mediated rejection of pancreas transplants, the current study reinforces the strong effect of donor-specific antibodies (DSA) on graft survival in simultaneous pancreas-kidney transplant patients. A total of 167 pancreas transplants (152 pancreas-kidney) were followed for the  development of HLA antibodies and DSA during 9 years of follow-up. […]

No Comments Posted in Pancreas Transplantation
November 18, 2011

Novel C1q assay reveals a clinically relevant subset of HLA antibodies independent of immunoglobulin G strength on single antigen beads


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The first pre-transplant cross-matches were performed using complement-dependent cytotoxicity (CDC) and showed immediate clinical benefits. Current HLA antibody test methods rely on Luminex single antigen bead (SAB) technology allowing for the sensitive identification of multiple DSAs even in highly sensitized patients. However, the clinical relevance of the HLA antibodies identified by the Luminex platform remains […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation