Posts Tagged ‘HLA antibodies’

November 18, 2011

Blood Transfusions in Organ Transplant Patients: Mechanisms of Sensitization and Implications For Prevention


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Sensitization to mismatched HLA can result from transplantation, pregnancy, and blood transfusions. As the extent of sensitization of a transplant recipient increases, the likelihood of finding an acceptable donor expressing HLA to which they have not generated HLA antibodies to decreases. Although advances have been made in desensitization protocols, little attention has been paid to […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
August 14, 2011

Modifiers of complement activation for prevention of antibody-mediated injury to allografts


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Antibody mediated rejection (ABMR) involves complement activation through the classical pathway due to donor specific antibody binding to allograft endothelium. The major strength of this review is its extensive overview of complement biology and its role in the damage it incurs to the allograft during episodes of ABMR. It also covers current approaches used to […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
August 14, 2011

Current methodologies for detecting sensitization to HLA antigens


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This comprehensive review discusses the progression of tests used for HLA antibody detection over the last 40 years highlighting the limitations of each of the techniques. Much of the discussion is focused on the latest single antigen bead technology including its many advantages, listing of limitations relating to the technology and translation into accurate interpretation […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
August 14, 2011

De Novo Anti-HLA Antibody After Pandemic H1N1 and Seasonal Influenza Immunization in Kidney Transplant Recipients


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Factors that lead to the development of de novo HLA antibodies or increase the strength of HLA antibodies in sensitized patients are incompletely understood. Transplant recipients are recommended to receive annual influenza immunization due to the high risk of complications in these patients. This study examined the effect of the new H1N1 influenza vaccine developed […]

No Comments Posted in Renal Transplantation
August 14, 2011

Desensitization in HLA-Incompatible Kidney Recipients and Survival


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Sensitization to HLA antigens results in increased waiting times for a transplant, which is associated with an increased risk of death. The current study examined whether performing living-donor renal transplants following desensitization resulted in a survival benefit when compared to equally sensitized patients on the wait list. A protocol using plasmapheresis and low-dose IVIg was […]

No Comments Posted in Renal Transplantation
July 4, 2011

Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches


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Panel reactive antibody (PRA) has been the common measure of sensitization for transplant patients that estimates the likelihood of finding a crossmatch-compatible donor. However, estimates using class I or class II PRA values makes it difficult to estimate the actual probability of finding a suitable donor. The calculated PRA (CPRA) is a readout of unacceptable […]

No Comments Posted in Renal Transplantation
July 4, 2011

Donor-Directed MHC Class I Antibody Is Preferentially Cleared from Sensitized Recipients of Combined Liver/Kidney Transplants


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Although simultaneous liver and kidney transplantation (SLKT) is uncommon, the liver’s ability to resist hyperacute antibody mediated rejection (AbMR) may allow the transplant to succeed despite the presence of pre-existing donor specific antibody (DSA). However, the long term impact of pre-existing DSA in SLKT is incompletely understood. This study analyzed a small cohort of SLKT […]

No Comments Posted in Liver Transplantation, Renal Transplantation
July 4, 2011

Summary of FDA Antibody-Mediated Rejection Workshop


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Although several agents are currently used for the treatment of antibody-mediated rejection (AbMR), the true efficacy of these therapies remains is unknown due to limited/ anecdotal experience. The following article reviews the results of the FDA-sponsored workshop on AbMR held in June of 2010. This workshop outlined the challenges facing the transplant community with the […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation, Transplant Infectious Disease
July 4, 2011

Early and Late Acute Antibody-Mediated Rejection Differ Immunologically and in Response to Proteasome Inhibition


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Antibody-mediated rejection (AbMR) requires the production of donor specific antibody (DSA) by recipient plasma cells and can present at early or late times post-transplant. Bortezomib is a proteasome inhibitor (PI) approved by the FDA for treatment of multiple myeloma that is increasingly being used off-label for the treatment of AbMR. This study, from one of […]

No Comments Posted in Renal Transplantation