Posts Tagged ‘HLA antibody’

October 11, 2013

Complement-binding anti-HLA antibodies and kidney-allograft survival


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The study by Loupy et. al. shows an important role for complement-fixing (C1Q+) donor-specific HLA antibodies (DSA) in risk prediction of kidney allograft loss. The study examined 1016 kidney transplant recipients transplanted across negative T- and B-cell cytotoxic crossmatches with subsequent testing by Luminex single antigen beads for the detection of complement-fixing as well as […]

No Comments Posted in Renal Transplantation
May 23, 2012

A Novel Pathway of Chronic Allograft Rejection Mediated by NK Cells and Alloantibody


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A major obstacle to the long-term survival of human heart allografts is chronic allograft vasculopathy (CAV), a pathologic state thought to be mediated by donor specific HLA antibody (DSA). This article defines the mechanism for DSA-mediated CAV in a mouse model. The analysis points to a clear role for NK cells in the generation of […]

No Comments Posted in Cardiac Transplantation
November 18, 2011

How to deal with presensitized candidates for heart transplantation?


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The increased sensitivity of current HLA antibody testing methods, utilization of ventricular assist devices, and application of calculated panel-reactive antibody (cPRA) values has translated into a larger number of sensitized patients awaiting heart transplantation. The current review thoroughly outlines the changes in HLA antibody testing methods, application, and limitations. Important details relating to risk factors […]

No Comments Posted in Cardiac Transplantation