Posts Tagged ‘immune monitoring’

June 21, 2013

Hypocomplementemia in Kidney Transplant Recipients: Impact on the Risk of Infectious Complications


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Post-transplant, there is no ideal measure of predicting how immunosuppressed an individual recipient is. Fernandez-Ruiz et al. assessed complement (C3 and C4) levels at 0,1,6 months post-kidney transplant in 270 patients. Those with C3 hypocomplementemia at month 1 had greater incidences of overall infection, bacterial infection and fungal infection up to month 6 post-transplant. This […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
January 28, 2013

Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study.


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Late CMV disease occurring after prophylaxis is a significant issue in CMV mismatched transplant recipients and predicting which patients will develop late CMV disease is difficult. In the last few years, immune monitoring has gained significant importance in the management of CMV. In this multicenter, prospective cohort study, the authors followed 127 D+/R- transplant patients […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study.


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Late CMV disease occurring after prophylaxis is a significant issue in CMV mismatched transplant recipients and predicting which patients will develop late CMV disease is difficult. In the last few years, immune monitoring has gained significant importance in the management of CMV. In this multicenter, prospective cohort study, the authors followed 127 D+/R- transplant patients […]

No Comments Posted in Transplant Infectious Disease
April 14, 2012

Can Immune Cell Function Assay Identify Patients at Risk of Infection or Rejection? A Meta-Analysis


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An assay to quantify how immunosuppressed an individual is would be a great asset in clinical practice. The Cylex ImmuKnow assay measures ATP-release from CD4+ T cells and is used in some transplant centers to guide management of immunosuppression. In this study, the authors performed a meta-analysis to determine whether this assay could identify the […]

No Comments Posted in Transplant Infectious Disease